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Continuity
Perseus' gladiator sandals change from opened toed to closed toed sporadically from scene-to-scene.
When the witch attacks Eusebios there is a shot from the eye view camera rushing towards him, though the witch holding the eye is not the one who grabs him.
On Charon's ferry when Io is training Perseus, she ends up lying down on the floor of the boat with coins all around her. The positions of these coins changes between shots, and some disappear completely.
Perseus' gladiator sandals change from opened toed to closed toed sporadically from scene-to-scene.
When Medusa creeps up on Ixas from behind and he turns around to face her, there's a string of hair stuck horizontally to his forehead where there wasn't in the previous shot.
While in Medusa's lair, Ixas reminds Eusebios to keep his eyes down and then begins to turn away, but in the very next shot, he's still facing Eusebios and turns away a second time.
Differences from mythological sources (including misuse of the names Titan and Kraken) are exempt from being listed as goofs, as are historical inaccuracies, especially when caused by reliance on Renaissance/Baroque artistic depictions.
When Spyros discovers Perseus as a baby with his dead mother Danae in the casket, Perseus' mother has brown hair. In a later flashback, Danae is blonde. Royal people have always been fond of using cosmetics including hair coloring.
Zeus has an American Bald Eagle which would live nowhere near Greece. Since this is fantasy, we can assume that the gods can transcend the laws of nature and geography.
At the end of the movie Andromeda says to Perseus that Argos will need a leader now, but both her and Perseus were facing the other way when her father was killed (distracted somewhat by the humongous Kraken trying to eat them) he was also obstructed by the crowd of panicking people.
In the Pegasus' final scene, its horseshoes are visible.
In the filming locations in the end credits, Dinorwic quarry is credited as being in "Wales, [in] England". Wales and England are different Countries in the United Kingdom.
According to Greek mythology, Cepheus, Cassiopea and Andromeda are respectively the King, Queen and Princess of ETHIOPIA. In the movie however they are represented as royals of Argos. Argos was/is not a city located in Ethiopia. Furthermore as Ethiopians they should have been dark skinned.
In Greek mythology king Acrisius was the father of Danaë, not her husband.