First time House has taken two cases.
At the beginning of the episode, the exterior scenes of the university campus were filmed at UCLA. House runs up the Janss steps from the Wilson Quad, and the team sits on Dickson Terrace, between Royce Hall and the Powell Library. However, the fountain in which House cools himself is a prop.
According to Cuddy, House comes storming into her office twenty-four times a year. Until this point, there were precisely 24 episodes in Season 2.
Kathleen Quinlan, who plays Richard's wife Arlene McNeil in this episode, also plays Jesse Spencer's (Dr. Chase) mother on Chicago Fire (2012).
Carter Jenkins, who plays Mark McNeil, also starred in Famous in Love (2017) with Bella Thorne. Her younger brother, Remy Thorne, appears in this episode.