Justina Machado, who plays Anna Nyles, appears in several episodes of the Grey's Anatomy spin-off Private Practice as Nurse Stephanie Kemp.
In the beginning, on Meredith's dry erase board, it says "2pm- eat eye boogies".
Faith Prince who plays Sonya in this episode also starred in My Father the Hero. Katherine Heigl also starred in My Father the Hero as the daughter.
Arye Gross plays a character named Adam. This was also his name in the 90's sitcom, Ellen.