This episode won an Emmy Award for Outstanding Prosthetic Makeup for a Series, Miniseries, Movie or a Special.
One of the doctors notices that George has nystagmus, an involuntary twitching of the eyes. Actor Pruitt Taylor Vince, who plays George, has this condition in real life.
House's guitar is a Gibson Les Paul.
The episode title, "Que Será Será," which is Spanish for "What Will Be Will Be," resembles an expression that George uses - "C'est la vie," French for "That's life."