In their 2018 reunion the cast stated that shooting Het Huis Anubis felt like their college experience.
Achmed Akkabi, who plays Appie in the series, left the show halfway through because he decided to pursue a degree in acting at the Toneelacademie in Maastricht. He was replaced by actor Kevin Wekker, which was poorly received by the audience.
Mara was supposed to suddenly leave in season 2, however Liliana de Vries insisted on creating a storyline for Mara's departure.
The story was originally intended to be for 8-year-olds, however the dark nature and complicated of the show made this almost impossible causing the creators to withdraw that statement and stated that the show was actually more appropriated for 10-16-year-olds.
Actors Sven de Wijn and Vreneli van Helbergen dated for a period of time while the show was airing.