This episode includes two reoccurring actors from the show "Bones." Joel David Moore and Carla Gallo play two of the squinterns on "Bones." Carla Gallo is also Dr. Sweets's girlfriend. Also, Erich Anderson guest-starred on "Bones" that same year.
At 28:50, House is watching a wrestling match featuring Christian Cage (Jay Reso) versus Abyss (Christopher Parks) for the NWA World Heavyweight Championship from TNA (now Impact) Wrestling's 2006 pay-per-view event, Lockdown.
Bailee Madison (Lucy) and Jennifer Morrison (Dr. Cameron) both star in ABC's Once Upon A Time, Madison as the younger version of Morrison's mother.
When treating the clinic patient, he implies that the patient brought in a urine sample from his friend, whom House refers to as "Eggs Benedict." This is a reference to one of Woody Allen's standup routines, where he has heartburn but doesn't want to go to the doctor, so he sends his friend, Eggs Benedict, who has the same symptoms.