Travis louse believes their world, a child's head, might be a living organism and might reject all lice if they degrade the head environment. This parallels the Gaia Hypothesis developed by James Lovelock in the 1970s. The notion that the entire Earth's biosphere, all its ecosystems, can be functionally a single organism was rather influential.
The scene where the louse with the melted face screams "help me help me" is a reference to Robocop
Kenny's uncovered face has, to date (August 2007), been shown four times on the show. This is one of the four episodes.
The title is a reference to the Ice Capades