The coyote that eats a roadrunner in Homer and Marge's fantasy sequence is the same one that was Homer's spiritual guide in S8E9 "The Mysterious Voyage of Homer".
Werner Herzog reprises his role as the head of a pharmaceutical company.
The crystal store that Marge goes to is called "FAO Quartz", a spoof of the New York City toy store FAO Schwartz. One of the books it sells is titled "Eat my Quartz", which is derived from Bart's early catchphrase "Eat my shorts".
Couch gag: Marge and the kids come in to find the sofa is just a backdrop painting. Homer comes in, tries to sit on the couch and falls through the backdrop.
One of the bins in FAO Quartz is labeled "mumbo jumbo" essentially admitting that the store's offerings are illegitimate