El Pantera is captured by a group of so called anti drug agents who want that him gives them information about "The Queen." He knows he has to escape. His best aid, the chief of police was supposedly death at the end of season 1.
El Pantera tries to return to Mexico and has a lot of problems to do it. La Reina is captured by the Army and "La Gorda's" daughter is getting in trouble.
Already in Mexico, El Pantera tries to find out if La Reina is indeed his supposedly deceased girlfriend. Diana in the meantime is about to get caught by the army.
La Reina wants to take revenge against her father "El Rubio" but he will not allowed it. The corrupt DEA agent kidnaps her and takes her back to Mexico City in order to recover the money El Pantera took away.