When the boys walk into the bar there is a beer tap that has been left running. Dean walks over and turns it off. The tap bears an "FB" logo for "Family Business Beer Co." - the brewery founded by Jensen Ackles, his wife Danneel and their family.
As Jack and the brothers talk near the end, there's a shot of a gas station with the name "Showalter" on it. John F. Showalter is a co-executive producer on the show and directed the episode among many others.
The diner that Jack is standing outside of is aptly named "Sammy's Highway Cafe est. 1977".
According to Jensen Ackles, the cast shot one day of this episode when the shutdown occurred, so only 18 episodes were completed filming when the COVID-19 pandemic forced filming to stop.
On the bar wall is a sign for 3 Sheeps Brewing Co.; while a lot of the beer-related signage and items throughout the series were for fictional beers and breweries, 3 Sheeps is a real brewery in Sheboygan, Wisconsin (as of 2020).