Guest star Christopher Lloyd and regular cast member Judd Hirsch costarred together many years earlier on Taxi (1978). The two share only one scene at the end of this episode. Hirsch's character (Alan Eppes) tells Lloyd's character (Ross Moore), "I have a little trouble picturing you as a hippie", which is an inside joke as Lloyd's character on "Taxi", the Rev. Jim "Iggy" Ignatowski, was the epitome of an aging hippie.
The character name of "Ross Moore" is a combination of the names of comic artist Alex Ross and comic writer Alan Moore.
In one of the scenes on the convention floor, Dr. Larry Fleinhardt is shown having purchased several pieces of comic memorabilia, most notably a "Fone Bone" plush doll from the independent comic series "Bone" by Jeff Smith.
Fittingly (for the comic book theme of the episode), two of this episode's guest stars are best-known for their participation in very popular science fiction franchises: Wil Wheaton (Miles Sklar) played Wesley Crusher on Star Trek: The Next Generation (1987), and Christopher Lloyd (Ross Moore) played Emmett "Doc" Brown in all three Back to the Future (1985) movies.
Just after Wil Wheaton appears, as he's walking through the convention, he passes a group of girls posing with a Captain Kirk cardboard cutout, on which the camera lingers as he walks away. Wil Wheaton starred in Star Trek: The Next Generation, a spin-off/sequel of the Kirk-led original Star Trek.