The emergency department staff continue to be held hostage by James Byrne which challenges Frank's leadership of the department leading him to make a shocking statement on the administration of the hospital.
Frank's leadership is put to the ultimate test when the ED team is held hostage and a deadly plan unfolds. In the bedlam that follows, threats are made, tempers are stretched and lives are lost. And at the end of it, Frank makes a decision that looks likely to cost him his job.