At first I didn't really knew what this series was about. I was more focussing on the background story of the world than the interview. After some googling I found out that these interviews were real and not some humor thing.
WARNING: If you treat the subject of the episode or it's guests as a spoiler don't read further!
This episode mainly goes about the perspective on drugs. Guest is David Drew Pinsky an American internist, addiction medicine specialist, and media personality. I really liked this episode and would recomend watching it a few times if you find it hard to follow, just like for the other episodes.
I think this series should be treated as a podcast. What I like about it is that the interviews are set in these bizar worlds that kind of interact with the interview together with the art style it makes for something interesting to watch.