Jack White replaced Morgan Wallen as the musical guest the day before the show was broadcast. Wallen's appearance was cancelled after videos surfaced showing him violating the show's COVID-19 protocols by attending a party while not wearing a mask and not social distancing during the week leading up to the program.
Jim Carrey spoofs Jeff Goldblum's roles in The Fly (1986) and Jurassic Park (1993). Carrey and Goldblum appeared together in Earth Girls Are Easy (1988), and Carrey was also considered for the role of Ian Malcolm.