This is the first time the Star Trek: The Next Generation (1987) cast has worked together since Star Trek: Nemesis (2002).
The song that Brian growls when Meg tries to take the crucifix out of his mouth is "The Right Stuff" by New Kids on the Block.
Stewie's teddy bear, Rupert, makes a cameo appearance. He can be seen in the claw machine in the background of the bowling alley scene.
Rob Lowe is reading Lawrence Schiller's "Perfect Murder, Perfect Town" before going to sleep. It makes his comment to Adam West about no murderers under the bed a joke.