The fat twins on motorcycles that the Curator refers to are Billy Leon and Benny Loyd McCrary, the world's heaviest male twins. As of 2018, they still hold this world record.
Marge has a son named Paulie. She is also noted for the movie Paulie (1998), where she keeps a bird with the same name. Tony Shalhoub also stars in 'Paulie.'
The person in charge of the museum where Togo the egg eating robot was played by Marc Vann, who also played the actor Hal Duncan, who was killed in Mr. Monk Goes to the Theater (2003).
At the end, Natalie exclaims "Shiver me timbers" to make fun of Adrian's desire to act like a pirate. In Mr. Monk Is on the Air (2007), Steven Weber's character used a similar term, "Jiggle me timbers," as a catchphrase.