In May 2021, both Emma Stone and Thompson stated that they would like to do a second Cruella film in the style of The Godfather Part II, serving as both a sequel and prequel.
In June 2021, Disney announced that a sequel is officially in the early stages of development, with Gillespie and McNamara expected to return as director and writer, respectively. In August 2021, Stone closed a deal to reprise her role in the sequel.