When Isis confronted Clark in the Egyptian exhibit, she picked up the "Dagger of Teth Adam." Teth Adam is the alter ego of Black Adam, Isis' husband in the DC comics and a villain whose power rivals Superman. Subsequently, he is the major archenemy of SHAZAM! (Captain Marvel aka Billy Batson).
Clark admits to Lois twice in this episode that he's the Blur but she doesn't realize it the first time because she was possessed by Isis.
This is the second depiction of Isis since the TV show SHAZAM! and the secrets of Isis hour (1975-1977).
This is the third episode of Smallville that Erica Cerra has appeared in. The first one was Season 4; Episode 16, "Lucy" where she portrayed Lex's aide. Next, Erica showed up in Season 5; Episode 5, "Thirst" as one of the blood thirsty vampire sorority girls. Now this, Season 10; Episode 5, "Isis" as the character of Adrianna Tomaz.
John Emmett Tracey went on to star as August Cartwright in Batwoman (2019).