Opening theme song performed by Patrick Stump of Fall Out Boy
Clay tells Quinn 'Open your eyes.' This is a recurring theme when people are in comas. Karen said it to Lucas after his car accident in Season 1, Lucas said it to Karen after she had Lily in Season 4, Keith said it to Lucas after he had his heart episode in the school and Lucas said it to Peyton after she had Sawyer in Season 6.
This episode's title originated from the track The Space Inbetween, originally sung by How To Destroy Angels.
Edwin Hodge who plays Will Bennet in this episode, is also Malcom in the show Good Sam which also has Sophia Bush in it.
Shantel VanSanten who plays Quinn James and Edwin Hodge who plays Will Bennett star in FBI: Most Wanted together.