At the time of filming, the actor who played the 102-year-old man was actually 88, and the actor who played his son was 84.
This is the second time House refers to the fictitious "Tiburon swab technology," previously mentioned in Season 6 Episode 5 Brave Heart (2009) for the same reason--to give a made-up medical justification for a lie.
This episode is the first sighting of a change in the movie posters in Wilson's office to include the movie Ordinary People. According to Robert Sean Leonard when asked about the movie posters on the set, he told the interviewer that if he had a choice he would choose this movie because if he were walking into an oncologist's office and saw that he would feel good. It also happens to be Leonard's favorite movie. After hearing the interview, the producers said said they would see what they could do and it appears they made the change.
Stephanie Courtney, who plays Flo in the Progressive Insurance commercials, makes an appearance in a serious role.
House jokes about having mono during his second year of med school. Hugh Laurie (House) actually had mono while he was in University.