- 007 is tasked with saving Great Britain from a maniac who's gotten his hands on military grade bio weapons.
- In Athens members of the G-20 are attending a photo shoot at the Acropolis, M and MI6 are on the lookout for an arms dealer known as Greco, he is preparing a suicide attack on the G-20 at the moment the photo is taken. James Bond is air dropped onto Greco's yacht, pursuing Greco to shore and nearly defeats him in a fistfight, but the vehicle containing the bomb is heading for the Acropolis, Bond gives chase and successfully overturns it detonating the bomb harmlessly.
Bond is granted a week's holiday which is interrupted when M contacts him on an urgent matter, a week prior an English bio-weapons researcher, Dr. Malcolm Tedworth, was presumed dead at sea after his yacht was found capsized in the English channel. An anonymous tip claims that Tedworth is alive and selling his latest research to criminals in Istanbul. Bond is sent to a construction site located over catacombs in Istanbul, where he oversees gangster/interrogator Bernin torturing Tedworth for the access code to the USB drive containing the bio-weapons research. Tedworth gives up the information and is executed, Bond intercepts the encounter and chases Bernin to some ruins where the latter hands over the information to a helicopter pilot. Bond interrogates Bernin, the data is being taken to Russian businessman Stefan Pomerov, Bond sends Bernin to a fatal plunge.
Pomerov is currently in Monaco, Bond is arranged a pick up with the local contact, Nicole Hunter, an English jewelry designer. Pomerov supplies her chemicals to alloy her jewelry and she's attending the opening celebration of his purchase of a casino. Inside Nicole stalls Pomerov while Bond searches his safe, inside are documents and a camera with video of Tedworth's interrogation, his research was on smallpox and anthrax antidotes to be used in the event of biological attacks, but the antidotes could be reverse-engineered as bio-weapons and he was tortured for the decryption method of the coded weaponization data. The alarm sounds and Bond and Nicole make a hasty exit.
The documents from the safe were invoices were for chemical manufacturing equipment sent to a reopened chemical factory in Siberia. Bond and Nicole head to the plant, she's travelling on alleged business with Bond posing as her bodyguard. Bond sneaks into the plant's computer center and discovers the plant is being used for bio-weapons development, Bond forcibly overloads the plant's core systems triggering a meltdown. Pomerov flees on a cargo train with Bond and Nicole in pursuit, their car lands on the train, which injures Nicole's hand, Pomerov boards an armed ground-effect vehicle while Bond and Nicole commandeer a military hovercraft, Bond jumps to the GEV and in the stand-off in the cockpit Bond shoots an override switch opening the door and flushing Pomerov out. The Russian army arrives to dispose of the bio-weapons while Nicole takes time off to recover from her injuries.
M calls Bond back for to London for debriefing, Bond refuses as they've yet to determine who sent the anonymous tip, that person wasn't Tedworth and wanted MI6 to remove Pomerov, according to Bernin's phone, only one call came from outside Turkey which Bernin ignored. Bond phones a Chinese agent, Colonel Ping and asks to meet in a Bangkok aquarium. Ping divulges the next clue, a Mongolian mercenary known as Rak, then is sniped dead. Bond chases the assassin through the streets ending in a crash which kills the assassin. Bond heads to a nightclub owned by Silk, an Australian criminal. Silk directs Bond to a boat house, as soon as Bond leaves Silk phones Rak's troops.
Bond corners Rak, but is knocked out and taken to Burma to be tortured. Rak presents his preferred torture implement, an ornate knife made from platinum and jewels, a phone call summons him back to Bangkok before he can harm Bond. Bond escapes confinement and commandeers an Osprey helicopter which is shot down near a dam. Bonds fights Rak at the top of the dam and destroys the Osprey Rak is on killing him.
In Monaco, Nicole is calling with several people over other researchers to be abducted for their creations, the meeting is interrupted with the arrival of a package, Rak's knife, Nicole leaves in a hurry. Bond chases her and stops her car on Millau Viaduct, she says was taken in with a rich, powerful man who offered her everything, she was the anonymous caller to MI6 and had Pomerov eliminated to prove herself. She refuses to tell as he's far beyond any agency and he has sent an automated drone to gun her down. With Nicole dead the trail has gone cold.
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