Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.
- Cuddy awakens to an empty bed. She gets up and as she starts for the bathroom a hand reaches out from under bed and grabs her ankle! It's House! He's very playful and pulls her down to him. She tells him that she has to pee and he lets her up, saying that it's okay, he has a book. Which he does. Seconds later Cuddy comes out to tell him that there is blood in her urine.
As House leaves Cuddy for her exam, the team talks about a new case: 16-year old Ryan (Brett DelBuono) spit up blood during a pick-up basketball game and the ER found no source in his lungs or GI tract.
During his first exam with Ryan, Taub (Peter Jacobson) notices the boy is depressed. Ryan says scratches on his belly aren't from cutting but admits to having smoked pot.
Cuddy's lab results are fine, but she schedules an ultrasound of her kidneys. House thinks that as hospital administrator she should not have to wait in line for the test. She politely disagrees.
Ryan is thankful Taub didn't tell his parents about the pot. Taub confides back in medical school he too had depression issues and "ended up hurting myself." He notices reds spots in Ryan's eyes.
Wilson (Robert Sean Leonard) performs the ultrasound and notices a mass in Cuddy's kidney.
House clearly is unable to focus on Ryan's case. He suggests they treat Ryan for staph.
After hacking into her schedule, House finds out Cuddy is meeting with her lawyer to set up a trust for Rachel. He thinks she should wait until the biopsy the following day before overreacting.
A peer comes to the hospital looking for prescription drugs Ryan sold him but wasn't able to deliver before getting sick. Taub takes Ryan's word for it when he says it was a one-time thing and gives him money to repay the guy.
Julia agrees to be Rachel's guardian.
We see one of Cuddy's dreams. It involves Rachel getting cartoonishly poor parenting from House after Cuddy died, seeming to be a parody of Two and a Half Men.
After Masters (Amber Tamblyn) congratulates Taub on being so trusting in Ryan, he immediately has second thoughts. Ryan tells them he has blood in his urine.
House tells the team about Cuddy's mass, still unable to fully concentrate on Ryan's case. The plan is to search Ryan's house for drugs.
An hour before Cuddy's biopsy, House is upset with Wilson for not comforting her. He is unable to be there for her himself.
Chase (Jesse Spencer) sits with Cuddy prior to her biopsy. She thinks House will eventually show up.
At Ryan's house, Taub finds a yearbook with some disturbingly violent doodling. They get word Ryan's lost all feeling in his right arm.
We get yet another dream sequence, this one consisting of House trying to save Cuddy from the rest of the team members in zombie form. This is House's dream.
House searches for info on Cuddy's tests while the team discusses Ryan. He orders tests for Ryan and has Masters examine recent biopsies to find which one is Cuddy's. The team isn't sure if the yearbook should be an issue or not.
Wilson again rips House continuing to avoid Cuddy. Masters comes in with word. Cuddy's biopsy was inconclusive. They won't know if she has cancer until they remove it in surgery. Cuddy is currently undergoing some imaging and House looks nervous.
House is now hiding at Foreman's place playing video games. Foreman (Omar Epps) also thinks he's making a mistake by not being with her.
We next see a black and white dream sequence, this time Cuddy and House's life as it were a "Leave It To Beaver" ideal. Rachel's doing great and Cuddy is 29 again. "None of this is possible," she says. Wilson shows up at her door with the scans.
House gets a call from Wilson with word additional masses have been found on her lungs, a typical sign of kidney cancer metastasizing. "She's dead," House says after hanging up.
Taub has taken some videos from Ryan's flash drive. They show him detonating pipe bombs in the woods and making threats about doing something to his school. Taub thinks he should show the police, but Foreman and Chase aren't sure. Nobody knows the whereabouts of House.
Wilson tells Foreman that Cuddy still thinks he'll show up. Wilson doesn't seem sure.
Taub tells Kay (Lesley Fera) and Todd (Ken Garito), Ryan's parents, the plan is to go into his brain to remove a clot. He mentions the video and they point out he'll probably be expelled. The father wants them to concentrate on getting the son well before worrying about anything else.
Taub continues to battle with himself over whether he should tell the cops what he knows.
Ryan's clot disintegrates during surgery and Foreman and Chase don't know why.
Yet another dream sequence, this one with House and Cuddy as Butch Cassidy and the Sundance Kid - the famous final scene of the movie where they take on an army. She is worried House might not be able to handle what is happening. "It might be too late," she says in the dream. She notices that he's eating in the dream and mentions that he's been eating in all her dreams, which Dream House tells her is a sign of stress in her real life.
Cuddy wakes up to find House standing by her bed. He apologizes for not being there and they hold hands.
With House now at Cuddy's side, the team has to figure out what's happening with Ryan without him. They aren't sure what was in his brain or why his liver function is deteriorating so quickly he'll be dead in a day. Cuddy has her surgery and the team still has no clue.
We get yet another dream sequence, this one a big Broadway song and dance number featuring House performing "Get Happy." Cuddy joins in as they repeat the refrain: "Forget your troubles, come on get happy." House's cane turns into a giant candy cane and Cuddy frowns at it as they dance.
Cuddy wakes up from surgery and House tells her she doesn't have cancer. The mass was benign and the spots on her lungs were an allergic reaction to medication. At this point, House thinks of something related to Ryan's case.
He's figured out Ryan really did have a staph infection, caused by an abscess. Taub guesses the source was the scratches on his stomach, from by plastic shrapnel from the bombs.
Julia sits with Cuddy after she returns home from the hospital. Before leaving, she makes reference to moving pills out of the reach of Rachel, saying "I worry because Rachel always calls them candy". Cuddy gets that look of epiphany usually reserved for House.
Cuddy shows up at House's place and tells him he must have been on Vicodin when he visited her before surgery. He confesses. He asks her how she knew and she says that her subconscious had been trying to tell her (each dream had house eating something - a lollipop, the candycane, etc. - when her sister mentioned Rachel thinking drugs were candy - it clicked). This leads to her having a revelation House will never be able to put her first. She breaks up with him over his heart-breaking protestations.
We see quick shots of Cuddy crying and Taub mailing a video to the police. We next cut to House sitting on the floor of his bathroom with pills in his hand. He takes two and pops them in his mouth.