The video game House plays while lying in bed is the one created by the developer that House and his team treated in Epic Fail (2009) from season six.
One of the houses that appears was used to film the opening sequence of the 2009 action film "Blood and Bone."
According to House, "Easy Rider auditions ended four decades ago." This refers to the 1969 counterculture movie where two hippie bikers, Wyatt and Billy, travel the U.S. on their motorcycles looking for freedom. Wyatt's motorcycle has a gas tank decorated like an American flag, similar to the one House looks at.