The fire station viewed by Christina and Owen in this episode is the same station used in the movie Ghostbusters (1984).
The exterior of Dr. Yang and Dr. Hunt's new firehouse apartment is Fire Station 23 at 225 E. 5th Street, Los Angeles, California, but digitally altered to look like Seattle and a lot less like the slums of L.A. This firehouse was used for the interiors of Ghostbusters headquarters in both Ghostbusters movies. The interior set seen on the show resembles like the interior of the real firehouse.
Every episode is named after a song. "Can't Fight Biology" is a song by DROP DEAD, GORGEOUS