This is the final on-screen appearance of BD Wong as a main cast member, though he remains in the credits for the duration of the season. Wong, however, would return future seasons as a guest star.
This is the final appearance of Melissa Sagemiller (A.D.A. Gillian Hardwicke). In the episode Reparations (2011), it is mentioned that Hardwicke was at a conference in Miami before being replaced by Casey Novak (Diane Neal) in that episode and Sherri West (Francie Swift) for the final episodes of the season.
Fatal insomnia is a rare genetic disorder where a mutation in a certain type of protein in the brain causes the patient to gradually lose the ability to sleep. After the onset of symptoms the patient is only able to sleep in progressively shorter periods until eventually the patient is only able to sleep for a few seconds at a time, these are called micro-sleep bursts.
The chronic insomnia causes irritability, paranoia, memory loss, loss of coordination and cognitive functions and eventually full blown dementia; death follows soon after the onset of dementia, the average survival time after onset of symptoms is 18 months.
The chronic insomnia causes irritability, paranoia, memory loss, loss of coordination and cognitive functions and eventually full blown dementia; death follows soon after the onset of dementia, the average survival time after onset of symptoms is 18 months.