There are no opening credits, but a fake one crediting Tim and Eric in the film-within-the-film, Diamond Jim.
James Quall and David Liebe Hart are the only "Tim and Eric" regulars who reprised their Tim and Eric Awesome Show, Great Job! (2007) counterparts.
When Taquito's (John C. Reilly's) roommate, Roy (Kirk Diedrich), is playing the video game Saints Row 2 (2008), a VHS box of The Little Mermaid (1989) can be seen on his table.
Some of the Tim and Eric Awesome Show, Great Job! (2007) regulars gather up with Tim and Eric before the end credits.