The owner of the bakery asks Velasco which part of Juárez he is from, to which he replies "Anapra". The city of Juárez is a large city, the largest city in the state of Chihuahua and has a population of 1.5 million. It is located on the Rio Grande river on the border with El Paso, Texas and the two cities make up the El Paso-Juárez bi-national metropolitan area, with a combined population of 2.7 million it is the second largest bi-national metropolitan area on the U.S.-Mexico border after San Diego-Tijuana. Juárez is one of the most violent cities in Mexico with it being an area of dispute between some of Mexico's largest drug cartels; the murder rate, especially against women, is very high. A significant amount of illegal drugs, weapons and victims of sex trafficking brought into the United States cross the border through or near Juárez. Puerto de Anapra, where Velasco is from, is one of the outlying communities of Juárez, it is west of the Rio Grande on the border with the state of New Mexico. It is one of the poorest communities in Juárez, and has some of the El Paso-Juárez area's highest rates of crimes like assault, drug trafficking, prostitution, murder, rape and sex trafficking.
"El Barrio" is Spanish for "the neighborhood" so the episode title translates to "Once Upon a Time in The Neighborhood".