This is the second time Kim Hyun-joong plays a character who considers medical career, the first time was in "Boys Over Flowers"(2009) as Yoon Ji Hoo.
Actor Seong-guk Choi, who played 21-year-old tennis team leader, was actually 40 years old while filming the series.
Based on the Japanese manga "Itazura na Kiss" by Kaoru Tada.
"Mischievous Kiss" takes over MBC's Wed. & Thurs. 21:55 time slot previously occupied by "Road No. 1" and followed by "Home Sweet Home" on October 27, 2010.