When Tobias returns to Sudden Valley and meets with Gob, Gob greets him with, "Good to see you, old friend!" taken (very loosely) from the song "The Sound of Silence," a running joke for season 4. In this case, the lyric "Hello darkness, my old friend," is modified; it was long referenced throughout Season 3 as well as an idea by the writers room that Tobias may be a black man with a rare skin condition.
Tobias (David Cross)' middle name is revealed as Onyango. Onyango is a name used by Luo People in Kenya and Uganda. Notably, Barack Obama's father's middle name is Onyango.
The Narrator (Ron Howard) notes that it's not the first time that Tobias (David Cross) has gotten on the wrong boat - he did the same thing in the Pilot (2003).
Signs on the set of Fantastic 4: An Action Musical have double sexual meanings: Fist! Poof! Drill! Stab.