In the episode "The Map" Axl says he wants to freeze himself when he dies and then become unfrozen when they cure is disease. This joke is a reference to the recurring joke on The Mary Tyler Moore Show where Ted, Phyllis, and Lars all have the same plan for when they die.
Frankie and Mike's will, a.k.a. the death napkin, is mentioned for the first time.
Frankie is remiss for having missed Aunt Ginny's 100th birthday, having only realized the milestone after her death. The actress that played Aunt Ginny, Frances Bay, died at the age of 92 a couple months prior to its airing. This episode concludes with a memorial to Frances Bay.
This episode was done because the actress who played Aunt Ginny, Frances Bay, had actually passed away.