Meredith Baxter plays Lea Thompson's mother. Both actresses became well known in the 1980s: Baxter played Elyse Keaton in Family Ties (1982), and Thompson played Lorraine Baines McFly in the Back to the Future (1985) trilogy. Both characters were mother to roles played by Michael J. Fox.
The episodes title references the 1939 painting, Las Dos Fridas, by Frida Khalo.
In Spanish, "Las Dos Fridas" means "The Two Fridas."
Sean Berdy's character doesn't appear this episode for first time, but he is still credited.