Matt is a werewolf desperate to find a cure for his condition. For one night each month he must lock himself in a cage to endure an excruciating physical transformation-- a genetic burden inherited from his now-deceased, alcoholic father. Despite the support of Alice, a ghost who has kept him bittersweet company since childhood, Matt has had enough of living a life that he is convinced can only end violently. He enlists the help of his friend Holly, a streetwise Bohemian witch, who leads him into the underbelly of a magical New York City in pursuit of a fabled cure. Together they cross paths with drug-addled gypsies, sketchy fast-talking warlocks, and hipster vampires. Holly reaches out for help from Nicholas Maspeth, an immortal professor who takes Matt under his wing and guides him towards his future-- while harboring more than a few secrets about Matts past. As an unlikely family forms around him, Matt wrestles with the monster that lurks within.