Grand Masti became the first A rated (adults only) film to gross 100 crore rupees at the box office.
A man laughed himself to death while viewing this movie.
Indra Kumar was inspired to make this film after watching films like Hangover and American Pie.
Ajit Singh Deol's erection under the table making it rise in Kachche Heere was later copied for Ritesh Deshmukh in Grand Masti.
Ajay Devgn, who starred in the prequel Masti (2004) as Inspector Sikander was offered the chance to make a special appearance in the film, but he was unable to. He however does appear on the main poster for the film in a picture frame as a reference to his character in the prequel.