This episode's plot is similar to that of Pokémon Heroes (2002):
- This episode marks the first physical appearance of Bianca and Latias since the aforementioned film.
- Latios and Latias going to Alto Mare at the end of this episode references the fact that many individuals of their species come and go from the city. This was originally revealed in the prologue of Pokémon Heroes: Latios & Latias, which was cut from the dub.
Jessie, James, and Meowth each individually return to the Team Rocket HQ.
Ash's team for this episode is Pikachu, Infernape, Swellow, and Hawlucha.
Ash and his friends save Latios from a Pokémon hunter.
Brock's Steelix is revealed to have learned Smack Down.