The piano music playing in the background while Cristina sees Owen is talking with his girlfriend is the same music that plays during "Beat Your Heart Out" (episode 5.14) when Owen and Cristina walk toward each other in the hallway.
A similar invention to Callie and Derek's bionic hand appeared on Private Practice.
Every episode is the name of a song. "Map Of You" is a song by Dusk Totem
In a later season would feature another Designing Women actor Hal Holbrook, Annie Potts was in this one.