Around 25,000 fans of the show signed a petition on Change.org to resurrect Brian. Seth killed Brian as a marketing stunt to make people talk and generate buzz. He, however, did not expect the reaction to exceed what they had in mind.
The episode received a 2.2 rating and was watched by a total of 4.58 million people. This made it the second most watched show on Animation Domination that night, beating American Dad! and Bob's Burgers but losing to The Simpsons with 6.78 million.
When the Griffins are at the vet and Peter sees a chicken and asks him a question, the chicken says "You have a bad reputation in the chicken community." Referring to Peter fighting the Giant Chicken throughout the show.
Brian was killed the same way in this episode as his human counterpart was in the episode "Road to the Multiverse" being struck by a car.
At Brian's funeral, Quagmire is looking at his phone and says, "Dammit, Ortiz, quit swinging at junk." This is a joke regarding the fact that Quagmire hates Brian this might be Quagmire taking one last shot at Brian.