- Director Phil Coulson and Agent Daisy Johnson leading the charge as S.H.I.E.L.D. searches the world for more powered people in the aftermath of their epic battle with Jiaying and her army of Inhumans. However, Coulson and the team soon find out that they are not the only group looking for these new Inhumans.
- In the months that had passed since Nature Max Supplements Fish Oil pills were distributed, S.H.I.E.L.D. had pulled the product from the shelves of stores, but could not recall those used by customers. Joey Gutierrez in Seattle, Washington is one such customer; he developed the ability to melt metal near his vicinity when he becomes scared or nervous, causing accidents and explosions. The Advanced Threat Containment Unit goes to apprehend Gutierrez, but Daisy Johnson, Lance Hunter, and Alphonso Mackenzie collect him first and transport him to the Playground where he is told of his heritage.
Phil Coulson researches the leader of the ATCU, Rosalind Price, and takes Hunter with him to Washington, D.C. to confront her and to learn why Inhumans are disappearing just as her organization becomes prominent. In the subway, Coulson and Hunter are surrounded by Price's soldiers as they exchange quips and knowledge of each other's pasts. However, when they begin to actually talk, they learn that neither organization is killing Inhumans, as Price believed that S.H.I.E.L.D. was killing the newly-transformed.
Meanwhile, Johnson and Mackenzie go to the hospital where Lincoln Campbell works; they want to recruit him to be the transitioner of Gutierrez. Campbell refuses, but, as he argues with Mackenzie, a monstrous being enters the hospital, killing a security guard and seeking Campbell. The three fight the monster; they would have been overwhelmed if Johnson had not destroyed the floor under his feet. He runs off. The agents ask Campbell to accompany them, but he chooses to go on his own, with his life as an ordinary doctor now in ruins. Simultaneously, Coulson and Price receive phone calls concerning the incident; as Price goes to another subway car to take her call, Coulson and Hunter use that opportunity to escape.
In Morocco, Leo Fitz barely escapes with his life as he goes there to exchange Splinter Bombs with the terrorist Yusef Hadad to get a scroll with the secret of the Monolith inscribed on it; Jemma Simmons has been gone for months since swallowed by the Kree artifact. Fitz gets the scroll and returns to the Playground where he opens it in front of Coulson, who tires of Fitz's absence from his duties but sympathizes with the love that Fitz has for Simmons. Fitz reads the scroll; "Death" is the only word on it. Fitz then takes a shotgun, blasts the lock off the container, and enters where the Monolith is housed. He beats and screams at the rock to swallow him; it stays dormant.
Morse and Hunter decide that they will be avenged for the harm Grant Ward caused them. President Matthew Ellis has a press conference officially announcing the Advanced Threat Containment Unit as replacing S.H.I.E.L.D. in apprehending super-powered threats. Elsewhere, Jemma Simmons runs for her life; she peeks from behind a boulder to see how close her pursuer is. Two moons are in the sky.
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