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Title: Night and Day (06 Nov 2016)
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| Episode cast overview, first billed only: | |||
| Michael Sheen | ... | Dr. William Masters | |
| Lizzy Caplan | ... | Virginia Johnson | |
| Caitlin FitzGerald | ... | Libby Masters | |
| Annaleigh Ashford | ... | Betty DiMello (credit only) | |
| Beau Bridges | ... | Dr. Barton Scully | |
| Betty Gilpin | ... | Dr. Nancy Leveau | |
| David Walton | ... | Bram Keller | |
| Michael O'Keefe | ... | Harry Eshelman | |
| Frances Fisher | ... | Edna Eshelman | |
| Danny Jacobs | ... | Bob Drag | |
| Nick Clifford | ... | Guy | |
| Corey Reynolds | ... | James Bell | |
| Joanna Canton | ... | Cherlyn Green | |
| Niecy Nash | ... | Louise Bell | |
| Jeremy Strong | ... | Dr. Art Dreesen | |
Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.
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