Wilmer Valderrama made a guest appearance on this episode. His girlfriend at the time, Demi Lovato, also made a guest appearance on the show in season 6 (Shiny Happy People).
This episode's title originated from the song I Wear the Face, originally sung by Mr. Mister.
This episode scored 7.35 million viewers.
Patients playing guitar or other musical instruments during awake brain surgery has happened for real. Some examples can be found on Youtube.