"I was feeling epic" is a line from Lexi to Stefan from season one's 162 Candles.
This is the first and only episode of the season not to feature a voice-over made by Ian Somerhalder.
While Mystic Falls was being evacuated, there was an old man in a wheelchair who appeared briefly. That was the same man in season 1 episode 5 who told Elena that there was something suspicious about Stefan; that he met Stefan in 1953, and he hadn't aged a day.
As of this episode Caroline will be the first non-lead character to appear in every episode of a season.
Never Say Never by The Fray played during the very first episode of The Vampire Diaries and the very last episode.