"Murphy's Law" might only affect men in the Murphy family, as in this episode Sara is depicted as a victim (like Melissa and Zack) rather than a cause of disaster (like Milo or their father).
The Doctor Zone Files is a parody of Doctor Who.
First appearance of Dakota and Cavendish, as pistachio vendors outside the 'Doctor Zone' premiere.
First appearance of Milo's older sister, Sara.
Captain Wilson is likely a reference to the film, Apollo 13, as he is voiced by Jim Hanks, who is the brother of Tom Hanks (who starred in the film). Wilson is also the name of the volleyball in a different Tom Hanks film, Cast Away.