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Spears has performed "Toxic" in a number of live appearances, including the 2004 NRJ Music Awards and in three of her concert tours.
It is accompanied by high-pitched Bollywood strings, sampled from Lata Mangeshkar and S. P. Balasubrahmanyam's "Tere Mere Beech Mein" (1981), and breathy vocals.
"Toxic" won Spears her first and only Grammy Award at the 2005 ceremony in the category of Best Dance Recording.
The accompanying music video for the song was directed by Joseph Kahn and features references to Blade Runner, The Seven Year Itch, and the films of John Woo.
The music video for "Toxic" was filmed over three days in December 2003, on a sound-stage in Los Angeles, California.
The song was written and produced by Christian Karlsson and Pontus Winnberg (known collectively as Bloodshy & Avant), with additional writing from Cathy Dennis and Henrik Jonback.