- Sheldon and Amy are thrilled when their super asymmetry theory is proven by two physicists, until they try to kick Amy off the Nobel nomination. Bernadette gets one of her drugs approved and wants a reluctant Penny to head the sales team.
- Sheldon and Amy "did it" in that their theory on super asymmetry has been confirmed by a pair of experimental physicists, Drs. Pemberton and Campbell with Chicago-based Fermilab, through their own work. President Siebert now believes they may be on track for that much sought after Nobel prize. As a sign to strengthen that thought, Drs. Pemberton and Campbell are on their way to Caltech to meet with Sheldon and Amy. Sheldon and Amy may find that this visit by their colleagues has consequences they didn't consider, and places Sheldon in a potential quandary. Meanwhile, the drug that Bernadette has been working on for three years has finally been approved for production and she wants Penny to head the drug's marketing team. Without telling her, Penny doesn't really want the job. While Penny tries to get out of it, Bernadette tries to manipulate the situation, like she has manipulated situation after situation, to her benefit.—Huggo
- As Dr. Cooper and Dr. Fowler present a new episode of "Fun with Flags" where they are accepting viewers' emails, they receive an email from the Fermilab near Chicago. The email is about their research paper on super-asymmetry and that work by Fermi-Lab employees have confirmed their theory. When Sheldon and Amy realize that their theory has been proven they start shouting "We did it!" over and over again.
The rest of the gang is now in Hofstadter's apartment when Howard says that Bernadette has some exciting news. The drug that she has been working on for five years has been accepted by the FDA and can now be marketed. She has a new anti-inflammatory drug that has no side effects, but she doesn't think it is that effective. Now Bernadette wants Penny to head up her sales team, though Penny doesn't think that she has enough experience. Penny wants to discuss it later while Bernie is determined that she takes the job. Sheldon and Amy burst in with their great news. Two physicists at Fermi-Lab were conducting an experiment on Kaon particle decay that actually supported their predictions on the higher order corrections pertaining to their asymmetry work.
Later Leonard tells his wife how proud he is of her being asked to head Bernadette's sales team. Penny isn't sure that it's the right move for her since she has to be working for mean little Bernadette.
In President Siebert's office he happily greets Dr. Fowler and Dr. Cooper and wants to hug them. Sheldon doesn't want to and that is fine with the President who only wants his star scientists happy. He tells them that the Fermi-Lab confirmation data makes their work a possible Nobel Prize winning effort. Fermi-Lab is sending out their two colleagues, Drs. Pemberton (Sean Astin) and Campbell (Kal Penn), to meet with them. Sheldon thinks it's wonderful that they are coming to LA to meet him. Sheldon and Amy would be Caltech's 39th and 40th Nobel Laureates.
In Bernadette's office, Penny comes in with some bad news. Her boss can't let her go to work on Bernadette's project. Bernadette suggests that she could talk to her and rip her a new one. Penny doesn't want Bernadette to intervene. Bernadette accepts her loyalty as Penny very quickly exits.
Sheldon and Amy are having lunch, President Siebert brings in Drs. Pemberton and Campbell who conducted the Kaon experiment. The Fermi-Lab scientists are excited to meet Amy and Sheldon. Amy wonders how they were able to design an experiment when the paper was only published a few months previously. The Fermi-Lab scientists' confirmation was an accident since they were working with Kaons for a long time and their data made no sense. Another colleague led them to the Cooper-Fowler paper which explained their data and proved the super-asymmetry theory. Instead of losing their jobs, they got a trip to LA. Also they don't even understand the concept of super-asymmetry.
In the cafeteria the guys try to talk about "Star Trek: Discovery", "Walking Dead" and "Black Mirror", but someone is behind in watching each of the series and they don't want to hear any spoilers. Sheldon complains that Pemberton and Campbell are on a press tour taking credit for his and Amy's work. Howard mentions that Christopher Columbus was looking for India not America. Leonard adds that the Nobel Prize board sometimes gives out the award to the experimental physicists over the theoreticians. The Nobel Prize for The Big Bang Theory went to the scientists who first thought their sensors needed cleaning until it was pointed out that they were picking up the background radiation from the big bang. It did not go to the ones who came up with the theory.
Penny was called into Bernadette's office to let her know that Bernie spoke to her supervisor who knew nothing about Penny's sales team offer. Penny counters that she had been taking the new antidepressant and that one of the side effects is lying. Bernadette wants to know why Penny doesn't want to work with her. Penny doesn't think that she is up to the project since her last one was for her high school yearbook which never got published. Also she'd be in charge of people who had college educations unlike herself. Bernie just wants her to be mean to them like she taught her.
Sheldon finds Pemberton and Campbell having dinner and confronts them about trying to steal his Nobel Prize. They tell Sheldon that super-asymmetry is the breakthrough that will give them all a Nobel Prize and that they have to work together. Since only three names can be on the Nobel Prize submission, Fermi-Lab is going to submit Sheldon, Pemberton and Campbell names and leave Amy out. The prize is for physics so they plan on leaving out the NeuroScientist. Fermi-Lab is submitting those three names and they have the best chance if Caltech submits the same names..
Discussing Penny's new job, Bernadette doesn't take kindly to Raj's comment that it's Penny's decision. Bernadette believes in Penny and wants to improve her even if it's against her will. She thinks she's really good at changing people's minds while her targets think that it was all their idea.
While having dinner, Amy keeps asking Sheldon what was on his mind since he is not eating and keep making clicking sounds with his tongue. He finally admits that Fermi-Lab wants to drop her name off the Nobel Prize submission and that if both organizations provide the same team, they have a much better chance of winning the award. Amy loves Sheldon and doesn't want to be in the way of something that her husband really wants.
Coming up the stairs Penny finds Bernie waiting for her. Bernadette apologizes for trying to push her friend. She has chosen her colleague Karen who is stronger and more confident. And she steals Penny's yogurt! Penny admits that she is nervous though she sees what Bernadette is doing and still agrees to take the job starting Monday morning.
Sheldon comes into the President's office to discuss their Nobel Prize submission. Sheldon insists that Caltech include Amy in their submission or not bother writing one at all. Siebert says that he will start a fight with Fermi-Labs; however, he respects Sheldon's decision and that Amy will be included.
Monday morning at the first sales team meeting, Penny describes herself as friends with Dr. Rostenkowski, Miss Cornhusker of 2001, still fits in the same jeans she did in 2001 and is the best damn salesperson there. She wants everyone to familiarize themselves with the specifications and marketing strategy for the new drug Inflamminex. She then tells them to memorize everything and then move on out. Go! Go! Go! Bernadette was very impressed. Penny replies that she was damn right that she was impressive. Bernie tells her to not use that tone with her. Right, Boss.
Title reference: Sheldon and Amy's reaction to their theory being proven, but then their reaction to Amy possibly being cut out.
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