In an alternate world much like our own, fearsome vampiric creatures terrorize the lands and people live in fear. Mercenaries called Blood Hunters are employed by a dubious scientific firm to hunt down these creatures and extract their vampire blood for the purposes of weaponizing them. Gabriela Chen is a former cop-turned-rogue hunter in search of the Aswang beast that killed her family, Naga. After an unsuccessful fight with Naga and the Kapre (Tree Giant) warlord, Gundra, she is rescued and brought back to a remote jungle training facility of a group of Blood Hunters called the Slayers. They are soon joined by a hybrid (half-human, half-Aswang) now on a vengeance trail, using syringes of Aswang blood to enhance his strength and survive. After the death of an Aswang queen, former Blood Hunter leader injected her blood into his own veins, transforming into a monstrous hybrid, eventually propagating a new breed of Aswang as his own army. Vanguarded by his lieutenants and a distant dark horse in the midst, their plan is to do destroy the Slayers including the avenging hunters, to curb and undermine mankind's chances against their elusive and growing threat.
—Vincent Soberano