The "Everybody Bleeds" musical number is inspired by the "Everybody Hurts" music video by the band R.E.M.
Aimee Mann sings the end credits cover song of Everybody Bleeds
On the wall in the bathroom, when Jessi sends Andrew to the shop, you can see written "For good time call 911" and "Svetlana + Dimitri 4 eva" inside a heart.
The brands of menstrual products Jessi's mom has include Pad Tie, Moon Warrior and Everybody Bleeds -- the name of the Episode and title of the song.
Andrew said "Are you there, Jessi? It's me, Andrew." This is a reference to the book, "Are You There, God? It's Me, Margaret".