This is PBS Kids's first animated reboot series.
T-Bone and Cleo are replaced by a male Dalmatian named Tucker and a female Australian Shepherd named Bailey in this animated series.
One contrast between this series and the 2000s original is the segment in this revival involves Willa the Kitten mostly interacting with mice while the original animated series featured Emily Elizabeth reading "Speckle" stories to Clifford.
Emily's old friends Jetta and Charley are absent from this reboot, including Jetta's dog Mac.