During Thanksgiving dinner, Missy declared that she was grateful there were two "Ghostbusters" cartoons. Annie Potts (Meemaw) played receptionist Janine Melnitz in the original Ghostbuster films.
The establishing shot for George Sr's interview in Oklahoma is a long view of McFarlin Library at the University of Tulsa.
In The One Where Emma Cries (2002), Chandler accidentally agrees to run his company's office in Tulsa, Oklahoma, the same city where George Sr has the job interview in this episode of Young Sheldon. By some bizarre coincidence, that episode of Friends was directed by Sheldon Epps.