Rose mentions that the Mexicans refer to her as "La Rosa Negra" which in English translates to "the black rose".
The ending of the film with Rose and Courtney is heavily inspired by the ending of The Thing (1982) with MacReady and Childs.
The character of Colton was initially written to be male in the first draft.
It is heavily implied through dialogue that Rose knows who Colton is and frowns on the unprofessional way that she conducts business.