I didn't think it would work without Roseanne but I also didn't think a new Star Trek series would work after the original. The humor is intact, the relationships are strong, Roseanne's death is dealt with in a dark, sad, and culturally appropriate manner. It's an excellent jumping off point for the show, future story lines, and character growth. It has the makings of being just as wonderful as the original if people can just get past their "It's Kirk or nothing!" I mean "It's Roseanne or nothing!" attitude.
Review of The Conners
