In an episode centered around Chase as he seeks healing and direction, really we get one of the most intimate looks into House himself as he watches his long-time colleague (and someone he actually cares about) process the tragedy that he takes blame for. In the tender final scenes, the dialogue and delivery struck me so profoundly when it first aired, that I have often thought of it during the past decade. I still felt it wrench watching it again, and reflected how our trauma, our relationships, and especially our choices, make us who we ultimately become. This is my favorite episode of the whole series, and it's fitting to be placed where it is in the timeline.